Major depression is one of the most prevalent disorders. In previous studies, cognitive, emotional, and metacognitive variables have been studied separately. The main problem of the present study is a comprehensive investigation of the differences between cognitive, emotional, and metacognitive variables in patients suffering from depression and normal peoples. The current study aimed to compare dysfunctional beliefs, emotional schemas and metacognitive beliefs in patients suffering from major depression and normal peoples. The sample (20 normal peoples and 20 patients) was selected conveniently from the statistical population which consisted of all the normal peoples and the major depressive  patients attending private psychotherapy clinics of the city of Urmia.The data were collected using Dysfunctional Attitudes Scale (DAS), Leahy Emotional Schema Scale (LESS) and Metacognitions Questionnaire (MCQ). The results indicated that there was a significant difference (P=0/001) between the two groups in terms of the three variables of the study. The findings highlight the importance of paying more attention to these variables in psychotherapy process of the major depressive patients.