The phenomenon of infertility, in addition to the medical field, have been discussed in behavioral and social sciences realm also. The aim of this study was to compare emotion regulation strategies and mindfulness among infertile women, fertile women with IVF and normal women. using casual-comparative design 120 women (40 infertile women, 40 women conceived by IVF and 40 normal fertile women) were selected and assessed by cognitive emotion regulation (CERQ) and five factors mindfulness questionnaire (FFMQ). The results of multivariate analysis of variance showed that infertile women and women conceived by IVF in comparison with normal fertile women have  more maladaptive cognitive emotion regulation strategies (self-blame, other-blame, rumination, catastrophizing) and more adaptive cognitive emotion regulation strategies (acceptance, positive reappraisal and putting into erspective) and lower mindfulness (observation, description, lack of judgment & non-reactive). The results indicate disturbance in the proper management of emotions, processing and biased assessment of environmental stimuli and a lack of awareness of the present, including venture factors for developing mood and anxiety disorders in infertile women & infertile women undergoing treatment.