Background Cancer is a genetic disease resulting in the uncontrolled division of cells, caused the effects of environmental factors and genetic disorders. Researches are emphasized on the effectiveness of mindfulness and acceptance and commitment therapy on psychological distress, death anxiety in patients with cancer.  Issue is that the mindfulness and acceptance and commitment therapy affect on psychological distress and death anxiety in patients with cancer. Aims:  The purpose of this study was to effectiveness of mindfulness education and commitment and acceptance therapy on psychological distress, death anxiety  in patients with cancer in Isfahan . Method: The research is semi-experimental. The statistical society includes all patient with cancer. The sampling method was 45 people who were purposefully selected based on the criteria of the research. The instruments were used as follows: DASS-21 Questionnaire, Templar Death Anxiety Inventory. Results: The use of path analysis in spss application was  Findings showed that there was a significant difference in the mindfulness training and acceptance and commitment therapy improvement of about  psychological distress and death anxiety (p <0.05). Conclusions: Therefore, it can be concluded that mindfulness training and commitment and acceptance therapy on variables of  psychological distress and death anxiety have a significant effect.