Background: One of the problems that female teachers experience is the conflict between work and family and vulnerability to emotional problems and depression is one of the consequences of this conflict. But can emotional therapy be effective in treating this depression? Aims: The purpose of the present study was to determine the effectiveness of emotion-focused therapy on reducing depression in female teachers. Method: The design of this study is quasi-experimental with pretest-posttest and control group. Data gathering tool is Beck Depression Inventory. The statistical population of the study was all female high school teachers in Qazvin in 1396. The sample consisted of 30 female teachers employed in secondary school, who were randomly divided into two experimental and control groups. The experimental group received 10 treatment sessions based on a researcher-made protocol (1397). Depression questionnaire scores were compared before and after the intervention in both experimental and control groups using analysis of covariance.groups. Results: The results of covariance analysis showed a significant difference in the depression score between the experimental and control groups and the effectiveness of emotionally-focused therapy on depression in female teachers. (p<0/001). Conclusions: Based on this, it can be said that the current treatment protocol is effective and can be used to reduce depression in female teachers.