According to statistics, cardiovascular disease is the leading cause of death in Iran. Although many of the disease prevention activities are related to reduction in case of developing the symptoms of these diseases, treatment must be undergone. According to previous studies, age and gender are factors that have a significant impact on recovery and recurrence of the disease. There are little Studies in this area in Iran and therefore, this study aimed to examine the relationship between age and gender with psycho logical well-being and quality of life in patients with cardiovascular disease after surgery.  The number of 139 patients that underwent cardiac surgery were selected with conveniently sampling and then were studied. The participants were asked to respond or complete depression, anxiety and stress scale (DASS-21) and SF-36 scale. Results showed that age and gender didn’t significantly affect patients with cardiovascular disease, psycho logical well-being and quality of life. According to these results, it can be concluded that heart disease can have the same effect on all patients in different ages and also, the impact of the heart disease in men and women is almost equal.