The purpose of this study was to investigate the relationship between locus of control (internal, external), and "A" and "B" personality types with social acceptance among substance abuser of substance abuse treatment centers in Kermanshah. Method of present research is descriptive-correlational. The study population included all substance abuser male and female clients of all substance abuse treatment centers in Kermanshah. Using a list, 100 persons were selected by simple random sampling method, and the questionnaires were distributed among them. Participants responded to the questionnaires with full consent .The tools which are used in this study are Rotter’s locus of control questionnaire, Personality types "A" and "B" Rattus & Spencer questionnaire and Marlow & Crown scale of social acceptance. Results show a significant predictive model with F= 15.35(p<0/001). Personality type and locus of control together can explain 24% of the changes in social acceptance (p<0/001). The regression analysis showed that locus of control with the impact factor of -0.42 (p<0/001) has the ability to predict the social acceptance, but personality type could not predict social acceptance.