Background: Studies have shown that cognitive behavioral psycholdarama group therapy is effective on improving emotional and relational problems but a study which addresses the impact of this therpay on interpersonal problems and difficulty in emotion regulation in divorced women has been neglected. Aims: the purpose of the current study was to examine the effectiveness of cognitive behavioral psycholdarama group therapy (CBPGT) on reducing interpersonal problems and difficulty in emotion regulation in divorced women. Method: This research is quasi-experimental with pre-test, post-test and a control group. The statistical population includes all divorced women who had referred to private counseling and psychological centers (84 centers) under the supervision of the General Department of Welfare in Mashhad in 2018. Among them, 24 people were selected by convenience sampling method and were randomly located into two experimental and control groups. Research tools were 60-item Interpersonal Problem Questionnaire (HP-60) and difficulty in Emotion Regulation Scale (DERS). Experimental group received sixteen 120-min of cognitive behavioral psycholdarama group therapy sessions (Treadwell, 2016). Data analysis was performed using multivariate covariance, variance analysis with repeated measurements and Ben Foroni post hoc test with the SPSS₂₀ software. Results: Cognitive behavioral psycholdarama group therapy has significant effect on reducing interpersonal problems and difficulty in emotion regulation in divorced women (p< 0/05). This result was also consistent in the follow-up. Conclusions: Cognitive behavioral psycholdarama group therapy can reduce interpersonal problems and difficulty in emotion regulation in divorced women.