Background: One of the issues that should be considered for methadone-treated patients is the quality of sleep in these patients. But the key question is, does the behavioral analysis approach affect the sleep quality of methadone-treated patients? Aims: The purpose of this study was to evaluate the effect of group training on behavioral analysis on improving sleep quality and its components in male patients treated with methadone. Method: The study was a quasi-experimental study with pre-test, post-test and follow-up and control group. The statistical population of this study consisted of all patients treated with methadone in one of Tehran's drug abuse treatment centers in 2015-2016. 40 patients were selected by convenience sampling method and randomly divided into experimental and control groups. (20 people) were replaced. The tools are: Pittsburgh Sleep Quality Questionnaire (Daniel J. Bayes et al., 1989) and Group Training Protocol on Mutual Behavior Analysis (Attadakht, Jafarian Dehkordi, Bashirpour & Narimani, 2015). Data were analyzed using covariance analysis test. Results: Interaction analysis approach had a significant effect on improving sleep quality of patients treated with methadone (P<0/05). Conclusions: Mutation therapy can be used to improve sleep quality of patients treated with methadone.