Background: Mindfulness-Based Stress Reduction is a group program that uses a combination of mindfulness meditation, physical awareness and yoga exercises to increase awareness. Numerous studies have shown the effectiveness of mindfulness-based stress reduction training in individual and social contexts. But the key question is: Is mindfulness-based stress reduction training effective for adolescents' empathy and empathy? Aims: The purpose of this study was to investigate the effectiveness of mindfulness-based stress reduction training on empathy and empathy in maternal adolescents in Ahvaz. Method: This was a quasi-experimental study with pre-test and post-test design and one month follow up with control group. The statistical population consisted of all male students of the first grade of high school in Ahvaz in the academic year 1396-96. Thirty consecutive male students were selected by convenience sampling method and were randomly assigned into two experimental and control groups (15 in each group). The research tools were: empathy and empathy scale in adolescents. Wozen, Patrusky, & Wankenburg, 2015) and mindfulness-based stress reduction training sessions (Chaskalone, 2011). Results: There was a significant difference between the experimental and control groups in empathy and empathy scores at posttest and follow up (P<0/001). Conclusions: Mindfulness-based stress reduction training can be used for empathy and empathy in maternal adolescents.