Background: Mental health and quality of life have a significant impact on the lives of inactive elderly women. But the main question is which yoga and Pilates exercises have the greatest impact on the mental health and quality of life of disabled older women? Aims: To compare the effectiveness of a Pilates and yoga training course on general health and quality of life in sedentary elderly women. Method: It was a quasi-experimental type. The statistical population consisted of sedentary elderly women residing in Tehran, 36 persons were selected by Targeted and accessible and were randomly divided into three groups of 12 pilates, yoga and control. The instruments included: at the beginning and end of the intervention, Goldberg and Hiller mental health questionnaires (1978), World Health Organization Quality of Life Scale (1996) and Pilates, Vincasanders et al. (2013). Data analysis was performed using covariance analysis and follow-up test. Results: Pilates and yoga training improved mental health and quality of life in sedentary elderly women (p<0/05); there was no significant difference between these two exercise methods in quality of life variable (p<0/05) but This difference was significant (p<0/05) in mental health variable and yoga practice had more significant effect. Conclusions: Yoga and Pilates exercises can be used to increase the mental health and quality of life of sedentary elderly women