Background: Much research has been done on the relationship between cognitive emotion regulation strategies, mindfulness, and perfectionism, but the role of these strategies in predicting emotional problems has been neglected. Aims: To investigate the structural model of cognitive emotion regulation strategies, mindfulness and perfectionism in predicting students' emotional problems. Method: This was a descriptive-analytical study. The statistical population of this study consisted of all male and female high school students in Tehran in the academic year of 2018-2019. 140 individuals (120 girls and 120 boys) were selected through multi-stage cluster sampling. Research instruments are: Garnefsky et al. (2001) Cognitive Emotion Regulation Questionnaire Scale (LABUND & LOBUND (1995)) Emotional Problems Scale (Depression, Anxiety and Stress Scale), Ryan & Brown Mindfulness Questionnaire (2003) and Tehran Multidimensional Perfectionism Questionnaire. (Besharat, 2007). Data were analyzed using structural equation modeling. Results: Cognitive emotion regulation strategies, mindfulness and perfectionism were positively associated with emotional problems (P<0/05). Conclusions: Emotional problems can be predicted by cognitive emotion regulation strategies, mindfulness and perfectionism.