Background: Assessing the personality aspects of schizophrenia can be effective in delivering effective treatment programs. But the key question is, is there a difference between the personality dimensions of men and women with schizophrenia and those with normal people? Aims: The purpose of the present study was to compare the gender dimensions of personality in patients with schizophrenia and normal individuals. Method: The study was causal-comparative. The statistical population consisted of all patients with schizophrenia referred to psychiatric clinic and living in maintenance centers and normal people in Tehran in 2017. 120 patients (60 patients living in the care center and 60 normal people) were selected by convenience sampling method. Research tools are: Cloninger's Nature and Character Questionnaire (TCI-56, 1993). Data were analyzed using multivariate analysis of variance. Results: The results showed a significant difference in the nature and character of the two groups (P<0/05). In particular, the highest difference between the two groups was related to self-efficacy and the least difference was related to reward. Conclusions: Overall, self-harm and avoidance in schizophrenia patients were more than normal individuals and in schizophrenia patients there was a significant difference between men and women.