Background: Numerous studies have examined early maladaptive schemas and marital satisfaction and psychological distress. But there is research on the relationship between early maladaptive schemas and marital satisfaction and the psychological distress of infertile women. Aims: the present study was conducted to investigate the relationship between early maladaptive schemas and marital satisfaction and psychological distress of infertile women. Method: The method of this study was descriptive and correlational. The statistical population included all infertile women in Tehran in 2019. A total of 260 infertile women were selected from two infertility centers in Tehran using the available sampling method. In order to collect data, the short form of Yang's initial maladaptive schema questionnaire(1998), Questionnaire 47 Enrich Marital Satisfaction Question (1989), and Kessler's psychological distress questionnaire (2002) were used. Data analysis was performed using Pearson correlation test and multiple linear regression analysis. Results: There is a significant relationship between incompatible schemas of abandonment, defect, dependence, obedience, emotional inhibition and unrelated criteria with marital satisfaction (P< 0/05). There is also a significant relationship between maladaptive schemas of abandonment, dependence, underdeveloped self-development, emotional inhibition, unrelated criteria, insufficient self-control, and entitlement to psychological distress (P< 0/05). Conclusions: Early maladaptive schemas are among the factors that lead to a decrease in women's marital satisfaction during the infertility period and increase psychological distress.