Amputation is one of the serious health problems that lead to harm and severe changes in emotions, cognitions, and behaviors of individuals. Most important psychological consequences of amputation are impaired body image, low self-esteem and desire for social isolation that in the case of chronic, will lead to clinical psychological disorders, especially depression. The aim of this study was use of psychodrama therapy to help coping with amputation. The present study as an empirical case study is used the single subject design (A-B). In addition, qualitative interview and the Beck Depression Inventory (BDI-13) were used to assessing the client’s problems. Changes in depression scores of the client from 24 to 3 and his statements on clinical interviews before and after treatment show that psychodrama is effective in reducing the psychological problems of the client and his adapting to the lack of limb. The findings show that flexibility and activity of psychodrama that facilitates the theatrical practices of daily life activities, helps adapting to the psychological pathologic consequences of amputation.